Adverse Effects of Long-Term Proton Pump Inhibitor Use: A Review for the Otolaryngologist
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Journal of Voice (Feb 2010) Chapman DB, Rees CJ, Lippert D, Sataloff RT, Wright SC;



OBJECTIVE: Proton pump inhibitors (PPIs) are the mainstay of current medical management for laryngopharyngeal reflux, and treatment often involves long-term use of this class of medications. The long-term adverse effects of PPI use have not been studied extensively, but several analyses have demonstrated epidemiological links between PPI use and adverse outcomes. These include altered mineral and vitamin absorption, orthopedic injury, acute coronary syndromes (ACS), and infectious risks.



STUDY DESIGN: A PubMed search was performed for subject headings, including PPIs and adverse outcomes. Relevant studies were included in this review. Studies were compiled, reviewed, and compared in a narrative form.



RESULTS: Several epidemiological links between PPI use and metabolic, infectious, cardiac, and orthopedic adverse outcomes were found. No definite causal effects were identified.



CONCLUSION: Given these epidemiological patterns, we recommend that the clinician be aware of these possible unintended consequences. In addition, we recommend consideration of dual-energy X-ray absorptiometry (DEXA) bone density scans in at-risk patients who have not been previously tested. We recommend consideration of vitamin B(12) and iron levels in selected patients who are at high risk. We also recommend close communication with our cardiology colleagues, as we attempt to ascertain the relationship between clopidogrel and PPI use. We recommend caution in the use of omeprazole in patients undergoing active treatment for ACS. Finally, we recommend consideration of Helicobacter pylori or serum gastrin level testing in patients with known risk factors for gastric carcinoma.

Swedish Cancer Institute First In The World To Offer GPS For The Body(R) To Assist With Precision-Gu
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Swedish Cancer Institute First In The World To Offer GPS For The Body(R) To Assist With Precision-Guided Prostate Cancer Treatments Part 3



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Opt for a safe and effective pill like ProCalisX
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ProCalisX is a boon for those who are suffering from Erectile Dysfunction (ED). Unlike other pills for overcoming ED like cheap cialis, ProCalisX has no side effects at all. It is a natural product that is 100% effective. While cialis takes 30/60 minutes to react, ProCalisX takes only 15 minutes. Apart from this, ProCalisX is a non-prescription pill, which is a unique blend of potent herbs and key vitamins. However, Cialis is a synthetic prescription drug that has many harmful side effects.

No doubt, Cialis may be effective to some extent but one should bear in mind that it is a pill that is shrouded with many harmful side effects. A study published in European Heart Journal on behalf of European Society of Cardiology stated that pills for curing ED like Cialis can cause cardiovascular problems like hypertension, chest pain, palpitations and others problems written by L.J. Vacanti and B. Caramelli. Another study published by American Journal of Ophthalmology acknowledged that intake of Cialis can cause vision changes, such as seeing a blue tinge on every object or having difficulty in figuring out the difference between the colors blue and green. According to a recent test conducted by FDA, some of the common side effects of Cialis are headache, indigestion, back pain, muscle aches, flushing, rash, sweating, bronchitis, throat pain, loose stools, nausea, upper abdominal pain, vomiting, vertigo, runny nose, fatigue, dry mouth etc.

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Cialis may also cause an erection that lasts longer than natural, a condition called priapism. This must be treated at the earliest or else it may cause permanent damage to the penis. However ProCalisX will never cause an unnatural erection.

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Features Cialis ProCalisX
Sublingual usage No Yes
Reaction time 30-60mins 15mins
Effective no. of hours 36 hrs 24hrs
Multiple attempts per dose No Yes
Side effects Many None
Prescription Required Not required
Price per dose $22.00 $2.50

The chart given has been prepared by the American Institute of Sexual Health (Dec, 2007). A test was conducted by Dr. Amanda Fox of the same institute, wherein 50 men out of 100 men suffering from ED between ages 45-50 were administered with ProCalisX and remaining were administered with Cialis. She also examined the sexual conditions of the men before being administered with the same. The chart shown below reflects her findings and shows that only 23% of the men were satisfied with Cialis and 77% of them were satisfied with ProCalisX.




Opt for a safe and effective pill like ProCalisX
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ProCalisX is a boon for those who are suffering from Erectile Dysfunction (ED). Unlike other pills for overcoming ED like purchase cialis, ProCalisX has no side effects at all. It is a natural product that is 100% effective. While cialis takes 30/60 minutes to react, ProCalisX takes only 15 minutes. Apart from this, ProCalisX is a non-prescription pill, which is a unique blend of potent herbs and key vitamins. However, Cialis is a synthetic prescription drug that has many harmful side effects.

No doubt, Cialis may be effective to some extent but one should bear in mind that it is a pill that is shrouded with many harmful side effects. A study published in European Heart Journal on behalf of European Society of Cardiology stated that pills for curing ED like Cialis can cause cardiovascular problems like hypertension, chest pain, palpitations and others problems written by L.J. Vacanti and B. Caramelli. Another study published by American Journal of Ophthalmology acknowledged that intake of Cialis can cause vision changes, such as seeing a blue tinge on every object or having difficulty in figuring out the difference between the colors blue and green. According to a recent test conducted by FDA, some of the common side effects of Cialis are headache, indigestion, back pain, muscle aches, flushing, rash, sweating, bronchitis, throat pain, loose stools, nausea, upper abdominal pain, vomiting, vertigo, runny nose, fatigue, dry mouth etc.

On the other hand, ProCalisX is 100% safe. Our herbal experts at Naturomeds Lab have conducted several trials and tests and have proved that ProCalisX does not cause any of the above-mentioned problems. Another point to be noted is that no prescription is required in case of ProCalisX and no need to follow any particular dose.

Cialis may also cause an erection that lasts longer than natural, a condition called priapism. This must be treated at the earliest or else it may cause permanent damage to the penis. However ProCalisX will never cause an unnatural erection.

Cialis is not to be taken if you are already taking medicines that contain Nitrates (Nitrates are mostly prescribed for chest pains and angina). But this is not the case with ProCalisX, you can take it along with any medicine. Cialis must not be taken if the patient is allergic to tadalafil (the active ingredient in Cialis) or any of its other ingredients. It also must not be taken with medicines called alpha-blockers. These include Hytrin (terazosin HCl),Flomax etc. Alpha- blockers are sometimes prescribed for prostate problems or high blood pressure. If Cialis is taken with certain alpha-blockers, the blood pressure can suddenly drop, making the patient dizzy or faint.

ProCalisX has none of the above restrictions. This particular pill has been formulated by our herbal experts at Naturomeds Lab using state-of-the-art technology. It has proven records of its effectiveness. Being a sub-lingual tablet (you can place it under your tongue so that it dissolves), it acts very quickly. The following table will bear testimony to the claims made by ProCalisX:

Features Cialis ProCalisX
Sublingual usage No Yes
Reaction time 30-60mins 15mins
Effective no. of hours 36 hrs 24hrs
Multiple attempts per dose No Yes
Side effects Many None
Prescription Required Not required
Price per dose $22.00 $2.50

The chart given has been prepared by the American Institute of Sexual Health (Dec, 2007). A test was conducted by Dr. Amanda Fox of the same institute, wherein 50 men out of 100 men suffering from ED between ages 45-50 were administered with ProCalisX and remaining were administered with Cialis. She also examined the sexual conditions of the men before being administered with the same. The chart shown below reflects her findings and shows that only 23% of the men were satisfied with Cialis and 77% of them were satisfied with ProCalisX.




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